Anti-globosides are very useful in the identification of globosides and immunotargeting cells that express globosides. Globoside is the P-antigen of the P blood group. An inability to convert globotriaosylceramide to globotetrahexylceramide leads to the Pk blood group phenotype. In this phenotype anti-globoside antibodies are produced.3 There have been indications that the antibodies directed against the globoside antigen on suppressor T cells stimulate the suppressor T cells, and that anti-globoside antibodies in cancer sera may play a role in causing immunodeficiency in cancer patients.4
应用类型
ELISA and TLC immunoblotting with peroxidase reaction
