Involucrin is a soluble cytoplasmic protein precursor of the epidermal cornfied envelope that becomes cross-linked by transglutaminase during envelope assembly. Involucrin is expressed in a range of stratified squamous epithelia， including the cornea which lacks a distinct cornfied layer. The protein is a useful marker of terminal differentiation. It is tightly linked to the onset of differentiation and first expressed in the immediate suprabasal layers of the epidermis.
Involucrin is mapped to 1q21 chromosome， among calpactin I light chain， trichohyalin， profillaggrin， loricrin， and calcyclin.
Involucrin’s structure is composed of a conserved region of about 75 amino acid residues followed by two very variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The size of the protein varies from 285 residues （in dog） to 835 residues （in orangutan）.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. Involucrin in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
