The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains， each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. The most striking feature of annexin 31 is a complete ablation of all four homologous type II calcium-binding sites in the conserved tetrad core. Although all 4 type II calcium-binding sites in annexin 31 contained amino acid substitutions that ablated their function， structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. Annexin-9 at a concentration of 0.1mg containing 10mM Tris， pH 8.0， 0.1% Triton X-100 and 0.002% NaN3.
保存建议
Annexin-9 although stable at 4℃ for 1 week， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
