The mammaglobin gene was first identified using a differential screening approach directed at the isolation of novel， human breast cancer-associated genes. Mammaglobin encodes a 10 kDa glycoprotein and is distantly relaetd to a family of epithelial secretory proteins that includes rat estramustine-binding protein/prostatein and human Clara cell 10 kDa protein （CC10）/uteroglobin. Mammaglobin， a mammary-specific member of the uterglobin family， is known to be overexpressed in human breast cancer. Studies suggest that mammaglobin is one of the first relatively mammary-specific and mammary-sensitive markers （85%）. Mammaglobin may be valuable used in a panel with BRST-2 （GCDFP-15） and ER in evaluating tumors of unknown primary sites.
SCGB2A2 （the mammaglobin gene） is located on chromosome 11， at locus 11q13. SCGB2A2 is member of the secretoglobin superfamily of which is a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa， secretoglobins appear to be involved in cell signalling， immune response， chemotaxis， and might also serve as transporters for steroid hormones in humans.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. Mammaglobin at 100ug/ml in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
