Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos， exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos- B include Fra-1 and Fra-2 genes. The 4 members of Fos gene family are: FOS， FOSB， FOSL1， and FOSL2. These genes encode leucine zipper proteins which can dimerize with proteins of the JUN family， thus forming the transcription factor complex AP-1. The FOS proteins act as regulators of cell proliferation， differentiation， and transformation. Alternatively spliced transcript variants encoding different isoforms exist for Fos B.
序列
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大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. FOS-B in 50mM Tris-Acetate， pH7.5， 1mM EDTA and 20% Glycerol.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature， this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
