人IGFBP-rP1也称为IGFBP-7、MAC25蛋白、PG12刺激因子、前列环素刺激因子和肿瘤衍生的粘附因子。 是一种256氨基酸糖蛋白,与IGF结合蛋白具有结构同源性。 以低亲和力结合IGF-I和IGF-II,刺激前列环素产生并引起细胞粘附。rn该IGFBP-rP1抗体是通过用连接到白喉类毒素的来自Ig样C2型结构域的14个氨基酸的肽免疫兔而制备的。 该肽序列是IGFBP-rP1所特有的。 该抗体识别人IGFBP-rP1,但不识别其它IGF结合蛋白或相关蛋白。 尽管该序列来源于人IGFBP-rP1,但该抗体应识别非人灵长类动物、牛、羊和猪以及潜在的几种其它物种中的IGFBP-rP1,尽管这应通过实验确定。 通过蛋白A亲和层析纯化免疫球蛋白级分。 该抗体适用于免疫测定、免疫印迹和免疫组织化学。 Human IGFBP-rP1 is also known as IGFBP-7, MAC25 protein, PG12 stimulating factor, prostacyclin-stimulating factor and tumour derived adhesion factor. It is a 256 amino acid glycoprotein with structural homology to IGF binding proteins. It binds IGF-I and IGF-II with low affinity and stimulates prostacyclin production and causes cell adhesion.nThis IGFBP-rP1 antibody was prepared by immunising rabbits with a 14 amino acid peptide from the Ig-like C2 type domain, linked to diphtheria toxoid. The peptide sequence is unique to IGFBP-rP1. The antibody recognises human IGFBP-rP1 but no other IGF binding protein or related protein. Although the sequence is derived from human IGFBP-rP1, the antibody should recognise IGFBP-rP1 in non-human primates, cattle, sheep and pigs and potentially several other species although this should be experimentally determined. The immunoglobulin fraction was purified by Protein A affinity chromatography. The antibody is suitable for use in immunoassay, immunoblotting and immunohistochemistry.
GroPep Bioreagents公司总部位于澳大利亚,成立于1990年,致力于向广大科研院所、生物技术及制药公司开发、生产和销售细胞培养级的活性生长因子(主要集中在胰岛素样生长因子(IGF)领域)、抗体及相关蛋白试剂,现有产品超过100多个,同时在世界范围内均设有分销商。公司在分子生物领域、发酵学及重组蛋白和单抗制备方面具有丰富的经验,在制造工艺方面,拥有大量专利技术,GroPep目前已通过AS/NZS ISO 9001:2016质量管理体系认证。