Arylsulfatase G（ARSG) is a member of the sulfatase enzyme family. Sulfatases are enzymes which hydrolyze sulfate esters from sulfated steroids， carbohydrates， proteoglycans， and glycolipids. Sulfatases are involved in hormone biosynthesis， modulation of cell signaling， and degradation of macromolecules. The ARSG protein exhibits arylsulfatase activity at acidic pH， as is characteristic of lysosomal sulfatases. The Arylsulfatase G enzyme localizes in the lysosomes. ARSG is inhibited by phosphate， which forms a covalent bond with the active site 3-oxoalanine. Arylsulfatase G is widely expressed， having very low expression in the brain， lung， heart and skeletal muscle.
