MMAE (monomethyl auristatin E) is an antimitotic agent that binds tubulin and inhibits the assembly of microtubules. Mc-VC-PAB-MMAE is a thiol reactive derivative of MMAE that contains a cathepsin cleavable valine-citrulline p-aminobenzylcarbamate linkage. Mc-VC-PAB-MMAE is used to prepare antibody-drug conjugates, such as brentuximab vedotin (Seattle Genetics). This HRP-MMAE conjugate is designed with similar linker chemistry as ADC and PDC prepared by our customer using CellMosaic’s Antibody MMAE Conjugation Kit (Cat#: CM11409) and Protein MMAE Conjugation Kit (Cat#: CM11413). It is synthesized at CellMosaic® for our customers' usage in horseradish peroxidase (HRP) based assay. A long flexible PEG linker is also incorporated in the conjugate to retain the activity of HRP and MMAE binding.nnThe final conjugate is purified to obtain a single MMAE-labeled HRP conjugate, and is lyophilized from PBS containing sugar-based stabilizer for easy shipping and storage. nnThe product is sold as 1 vial of 0.5 mg (Cat# CM53209-0.5MG) or 4 vials of 0.5 mg (Cat# CM53209-2MG). For bulk orders, please contact us for a quote.
