Ang 1-7 is a biologically active peptide of the renin-angiotensin system. Ang I-7 binds the Mas receptor, which mediates vasodilation and the antiproliferative actions of the heptapeptide. Endogenous Ang 1-7 is generated by angiotensin-converting enzyme 2 (ACE 2) mediated degradation of Ang II. It can also be formed from Ang I or Ang II by other peptidases.
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Ang 1-7是肾素-血管紧张素系统的一种生物活性肽。 Ang I-7与Mas受体结合,后者介导血管舒张和七肽的抗增殖作用。 血管紧张素转换酶2(ACE 2)介导的血管紧张素Ⅱ(Ang Ⅱ)降解产生内源性Ang 1-7。 它也可以由Ang I或Ang II通过其它肽酶形成。