Signal-Seeker 泛素化富集试剂盒（10 assays）-Signal-Seeker Ubiquitin Enrichment Kit (10 assays)-细胞分析试剂盒-艾美捷科技有限公司

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背景资料: Poly-ubiquitination of a target protein is a well-established mechanism to regulate proteasome mediated degradation; additionally, both poly- and mono-ubiquitination have been shown to control critical protein functions like protein: protein interaction, spatial regulation, and crosstalk with other post-translational modifications (PTMs). Because of its ubiquitous nature, and its clear importance in regulating an array of protein functions, it is no longer practical to leave the investigation of ubiquitination (Ub) to just a few ubiquitin experts. However, user-friendly tools are needed in order for non-Ub-specialists to efficiently study whether and under what conditions, their target protein is ubiquitinated. Here we describe a newly developed Signal-Seeker Ub kit (BK161) that rapidly identifies both poly- and mono-Ub for any target protein. To highlight the utility of this kit, detection of endogenous poly- and mono-Ub of Rac1 as well as chain specific ubiquitin detection was performed. In particular we compare the kits ubiquitin affinity beads, UBA01 with other commercially available ubiquitin affinity reagents. Collectively, these studies show that UBA01 is the most robust and precise mono- and poly-Ub detection reagent available, and utilization of the comprehensive BK161 kit will provide the best path to determining if a target protein is ubiquitinated.

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其他: Cytoskeleton公司成立于1993年，专注于生物化学和细胞过程研究中的纯化蛋白和便捷试剂盒开发与生产。公司提供药物筛选、信号转导、蛋白质转录后修饰（PTM）、细胞骨架研究相关的系列试剂盒和产品，尤其以细胞骨架相关研究见长，既能满足于样品较少的科学研究，也可以用于小规模筛选研究和高通量大规模筛选研究。此外，公司还提供微管蛋白，肌动蛋白，小G蛋白，GAPs，GEFs等现有产品的药物筛选服务。