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中文名称

重组EGFR,His,人

英文名字
RecombinantEGFR,His,Human
供应商
Bioworld
产品货号
BK0353
产品报价
¥询价/10ug
产品说明书
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产品新闻
背景资料
Epidermal Growth Factor Receptor (EGFR) belongs to a family of tyrosine kinase receptors including Human EGF Receptors (HER) 2, 3, and 4 which all play important roles in cell growth and differentiation. Their primary ligands are EGF, Heparin-Binding EGF and Transforming Growth Factor α. Upon ligand binding, EGFR undergoes asymmetric dimerization, composed of an “activator” and a “receiver”. EGFR and its family members are disregulated in numerous cancers. In particular, EGFR is overexpressed in many epithelial solid tumors. Evidence suggests EGFR is an excellent target for pharmacologic intervention in Non Small Cell Lung Cancer (NSCLC) due to its high level of expression and prominent role in tumor growth and metastasis. Recombinant human Epidermal Growth Factor Receptor (rhEGFR) with C-terminal 6xHis-tag produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 627 amino acids. rhEGFR has a molecular mass of 80kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
序列
LEEK KVCQGTSNKL TQLGTFEDHF LSLQRMFNNC EVVLGNLEIT YVQRNYDLSF LKTIQEVAGY VLIALNTVER IPLENLQIIR GNMYYENSYA LAVLSNYDAN KTGLKELPMR NLQEILHGAV RFSNNPALCN VESIQWRDIV SSDFLSNMSM DFQNHLGSCQ KCDPSCPNGS CWGAGEENCQ KLTKIICAQQ CSGRCRGKSP SDCCHNQCAA GCTGPRESDC LVCRKFRDEA TCKDTCPPLM LYNPTTYQMD VNPEGKYSFG ATCVKKCPRN YVVTDHGSCV RACGADSYEM EEDGVRKCKK CEGPCRKVCN GIGIGEFKDS LSINATNIKH FKNCTSISGD LHILPVAFRG DSFTHTPPLD PQELDILKTV KEITGFLLIQ AWPENRTDLH AFENLEIIRG RTKQHGQFSL AVVSLNITSL GLRSLKEISD GDVIISGNKN LCYANTINWK KLFGTSGQKT KIISNRGENS CKATGQVCHA LCSPEGCWGP EPRDCVSCRN VSRGRECVDK CNLLEGEPRE FVENSECIQC HPECLPQAMN ITCTGRGPDN CIQCAHYIDG PHCVKTCPAG VMGENNTLVW KYADAGHVCH LCHPNCTYGC TGPGLEGCPT NGPKIPSHHH HHH
来源宿主
SF9 insect cells
溶解建议
Reconstituted in ddH2O at 100 μg/mL.
保存建议
Lyophilized recombinant human Epidermal Growth Factor Receptor (rhEGFR) remains stable up to 6 months at -80
其他
Bioworld是专一服务于生命科学研究的专业技术型企业,Bioworld品牌创立以来拥有10000多种常规产品现货,现有8000多种现货抗体,以及其他IVD原料,蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势,其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利
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