Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin （Catalog No. 70665）. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase （FAAH） and the transient receptor potential vanilloid-type 1 （TRPV1） channel， reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 16-carbon palmitoyl moiety have not been studied. However， replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation （IC50 = 0.76 uM） without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine （IC50 > 50 uM）.
产品描述
A hybrid molecule patterned after N-arachidonoyl serotonin； while saturated 11- or 12-carbon fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation （IC50 = 0.76 uM） without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine （IC50 > 50 uM）， the effects of palmitoyl serotonin are unknown
