8-hydroxy Guanosine is produced by oxidative damage of RNA. It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-hydroxy guanosine (5-8 mM) is added to Friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.
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8-hydroxy Guanosine is produced by oxidative damage of RNA.{1239,5125} It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-hydroxy guanosine (5-8 mM) is added to friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.{1453,886}