N.omega.-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). N.omega.-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a Ki value of 57 nM. The Ki values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 uM, respectively. N.omega.-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.
产品描述
A potent and selective competitive inhibitor of nNOS (Ki = 57 nM; bovine); exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine; Ki = 180 uM) and endothelial (bovine; Ki = 8.5 uM) isoforms of NOS, respectively