The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue， P564， by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase （HIF-PH）. DMOG is a cell permeable， competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells， at concentrations between 0.1 and 1 mM. DMOG is therefore expected to act as a pro-angiogenic compound， acting via the HIF-1α system.
产品描述
A cell permeable， competitive inhibitor of HIF-1α prolyl hydroxylase； stabilizes HIF-1α expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM
