Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi， in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase （Ki = 0.28 nM）， the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 （IC50 = 15 nM） via apoptosis. Myriocin suppresses replication of the hepatitis C virus （HCV） in a murine model.
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Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi， in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A.{8482} Myriocin is a potent inhibitor of serine palmitoyltransferase （Ki = 0.28 nM）， the enzyme that catalyzes the first step of sphingolipid biosynthesis. {14764} It disrupts substratum adhesion of melanoma cells.{14763} It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 （IC50 = 15 nM） via apoptosis.{14764，2816} Myriocin suppresses replication of the hepatitis C virus （HCV） in a murine model.{14762}
