Niclosamide (Item No. 10649) is an antihelminthic compound that affects mitochondrial metabolism in parasitic worms.{29804,17472} It specifically inhibits the signal transducer and activator of transcription 3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mTORC1 signaling (complete inhibition of S6K phosphorylation at 3 μM).{17472,18706} Niclosamide ethanolamine is a more water soluble, salt version of niclosamide that has been used to increase energy expenditure and lipid metabolism in mice.{27785} At 125 mg/kg/day, niclosamide ethanolamine prevented high-fat diet-induced hepatic steatosis and insulin resistance and improved glycemic control in db/db mice.{27785}
产品描述
A more water soluble, salt version of niclosamide that has been used to increase energy expenditure and lipid metabolism in mice; 125 mg/kg/day prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice
