5-溴-7- [5-脱氧-5-[[3-[[[[4-（1,1-二甲基乙基）苯基]氨基]羰基]] [氨基]丙基] [（1-甲基乙基）氨基]-β-D-呋喃呋喃糖基] -7H-吡咯并[2,3-d]嘧啶-4-胺-5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine-生化试剂-艾美捷科技有限公司

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中文名称: 5-溴-7- [5-脱氧-5-[[3-[[[[4-（1,1-二甲基乙基）苯基]氨基]羰基]] [氨基]丙基] [（1-甲基乙基）氨基]-β-D-呋喃呋喃糖基] -7H-吡咯并[2,3-d]嘧啶-4-胺

英文名字: 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

背景资料: Dot1L is a protein methyltransferase (PMT). It is the only enzyme known to methylate histone 3 at lysine 79 (H3K79), where it catalyzes mono-, di-, and trimethylation.{21195} Proper Dot1L function is necessary for transcriptional activation of many genes, DNA damage repair, and cell cycle regulation.{21198} SGC0946 is a potent inhibitor of DOT1L (IC50 = 0.3 nM) developed by Structural Genomics Consortium laboratories (probes/SGC0946">(www.thesgc.org/chemical-probes/SGC0946)). It is over 100-fold selective over other PMTs. It is active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively). SGC0946 is a brominated analog of EPZ004777, an S-adenosylmethionine-competitive inhibitor of DOT1L.{27033} Both SGC0946 and EPZ004777 selectively kill mixed lineage leukemia (MLL) cells, in which DOT1L is aberrantly localized via interaction with an oncogenic MLL fusion protein.{27033}

产品描述: A potent inhibitor of DOT1L (IC50 = 0.3 nM); over 100-fold selective over other PMTs; active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively)

其他: Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.