The Insulin-like Growth Factor 1 （IGF-1） Receptor is a transmembranereceptorthat is activated by IGF-1and by the related growth factor IGF-II. It belongs to the large class of tyrosine kinasereceptors. This receptor mediates the effects of IGF-1， which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscleand other target tissues.
IGF-1R （Insulin-like Growth Factor-1 Receptor） consists of alpha- and Beta-subunits， which are disulfide-linked in a Beta-alpha-alpha-Beta configuration in the mature receptor. The alpha-subunit is completely extracellular， while the Beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
