PGAM1 is part of the phosphoglycerate mutase family. PGAM1 is an essential component of glucose and 2，3-BPGA（2，3-bisphosphoglycerate) metabolism and catalyzes the reversible reaction of 3-phosphoglycerate（3-PGA) to 2-phosphoglycerate（2-PGA) in the glycolytic pathway. PGAM1 is a dimeric enzyme containing， in different tissues， different proportions of a slow-migrating muscle（MM) isozyme， a fast-migrating brain（BB) isozyme， and a hybrid form（MB). PGAM1 mutations lead to muscle phosphoglycerate mutase deficiency， a.k.a. glycogen storage disease X.
