Near-IR CF® dye Annexin V conjugate is Annexin V labeled with our superior near-IR fluorescent dyes. Annexin V is a 35-36 kDa protein that has a high affinity for phosphatidylserine (PS). In normal viable cells, PS is located on the cytoplasmic surface of the cell membrane. In apoptotic cells, however, PS is translocated from the inner to the outer leaflet of the plasmic membrane, making itself available for Annexin V binding. CF® dyes are Biotium's line of next-generation fluorescent dyes with advantages in brightness, photostability, and conjugate specificity compared to other fluorescent dyes. Far-red/near-IR fluorescent CF®770R dye has excitation/emission at 680/701 nm. Near-IR CF® Dye Annexin V does not contain azide or other potentially toxic materials, and thus is suitable for in vivo imaging.
