FAM-amido hexamethylene carbamate-PAB-Cit-Val-Alkyne is a cleavable ADC linker with fluorescein that undergoes enzymatic transamination. The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The Val-Cit linker was designed to be cleaved by cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
