CFLAR contains two death effector domains （DEDs） and a caspase-like domain. CFLAR may play a critical role between cell survival and cell death pathway in mammalian cells. CFLAR also interacts with adapter protein FADD and caspase-8 and -10， and potently inhibits apoptosis induced by all known death receptors DR3 （death receptor 3）， TRAIL-R （TNF-related apoptosis-inducing ligand receptor） and TNFR1 （tumor necrosis factor receptor 1）.
应用类型
ELISA， Western blot
免疫原
Anti-human CFLAR mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CFLAR amino acids 1-376 purified from E. coli.
