CEBPB is an intronless gene and its protein is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. CEBPB can also form heterodimers with the related proteins CEBP-alpha， CEBP-delta， and CEBP-gamma. CEBPB is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene， as well as to regulatory regions of several acute-phase and cytokine genes. In addition， CEBPB can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
应用类型
ELISA， Western blot
免疫原
Anti-human CEBPB mAb， is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CEBPB amino acids 1-271 purified from E. coli.
