TPMT， thiopurine S-methyltransferase， is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. TPMT activity exhibits autosomal codominant genetic polymorphism， and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity.
应用类型
ELISA， Western blot
免疫原
Anti-human TPMT mAb， is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TPMT amino acids 1-245 purified from E. coli.
