中文名称

N-糖化半乳糖基鞘氨醇

英文名字

N-Glycinated galactosylsphingosine

供应商

Matreya

产品货号

2091-1

产品报价

￥询价/1mg

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868

产品新闻

背景资料

N-Glycinated galactosylsphingosine is an analogue of the important biomolecule galactosylsphingosine (psychosine). It is ideal for use as an internal standard in the extraction and mass spectrometry analysis of galactosylsphingosine from natural samples.1 The free amine group gives this product very similar physical characteristics to the natural glycolipid while the glycine adds an additional 57 units to the molecule making it easy to detect by mass spectroscopy. Galactosylceramides are found primarily in neuronal tissues and are the major glycosphingolipids in the central nervous system. They constitute the largest single component of the myelin sheath of nerves and act, along with other components, to form part of the structural support of the myelin sheath.2 They are involved in a very wide range of biological activities such as cell agglutination, intracellular communication, cellular development, and antitumor/cytotoxic effects.3 Galactosylceramides can be metabolized into sulfatide which is also abundant in the nervous system and myelin sheaths. Krabbe disease is a demyelinating disease caused by a lack of the enzyme galactosylceramidase.4 This deficiency results in the accumulation of galactosylceramide and galactosylsphingosine in cells, making both of these lipids potentially useful biomarkers in Krabbe disease diagnosis.4 Galactosylsphingosine is highly cytotoxic and cannot be degenerated further in Krabbe cells due to the lack of galactosylceramidase. Although GM1 gangliosidase can degrade galactosylceramide it cannot degrade galactosylsphingosine. Galactosylsphingosine can cause oligodendrocyte death, astrocyte activation and the formation of multinuclear globoid-like cells. It is present naturally in small amounts and has a role in the sphingosine-1- phosphate receptor superfamily. Galactosylsphingosine has been found to induce cell apoptosis, cytokine activation, phospholipase activation, peroxisomal dysfunction, and altered calcium homeostasis.5

产品描述

N-Glycinated cerebroside|N-Glycinated galactosylceramide|N-Glycinated psychosine

产品形式

该N-糖化半乳糖基鞘氨醇产品为固体形式

保存建议

对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

其他

Matreya LLC是一家脂质生化公司，致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富，生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体（生育酚和生育三烯酚）。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：