sis factor α and platelet-derived growth factor. Niemann-Pick Type C, a neurovisceral lysosomal cholesterol trafficking and lipid storage disorder, leads to an accumulation of multiple lipids, including excess unesterified cholesterol, GM2 and GM3 gangliosides, lactosylceramide, and glucosylceramide.(3) Lactosylceramide is also important in the activation of platelet/endothelial cell adhesion molecule-1 which causes adhesion and diapedesis of monocytes/lymphocytes.(4) In animals neutral lyso-glycosphingolipids occur naturally in small amounts. lyso-Lactosylceramide can release calcium stores from microsomes in the brain cortex and cerabellum.(5) Other lyso-glycosphingolipids also release calcium but in a mechanism different from lyso-lactosylceramide.
