Anti-ganglioside GD1b (anti-GD1b) is very useful in the identification of disialoganglioside GD1b and in immunotargeting cells expressing disialoganglioside GD1b. Several gangliosides have been found to have elevated expressions in tumor cells. Many therapeutic treatments of tumor cells are being investigated using antibodies to target cells that express these elevated levels of gangliosides. GD1b may be a target molecule for autoantibodies in some patients with acute sensory ataxic neuropathy.3 Anti-GD1b has been found in some patients with Guillain–Barré syndrome (a disorder affecting the peripheral nervous system) and may contribute to the pathogenesis of sensory disturbance and demyelination.4
应用类型
ELISA and TLC immunoblotting with peroxidase reaction2
