This sphingomyelin contains C17:0 which is an unnatural fatty acid making it an ideal internal standard and biological marker.1 The activity of C17 sphingomyelin is very similar to natural sphingomyelin due to their structural similarities.2 Sphingomyelin is found in mammalian cell membranes, especially in the membranes of the myelin sheath. It is the most abundant sphingolipid in mammals and is thought to be found mostly in the exoplasmic leaflet of the membrane although there is also evidence of a sphingomyelin pool in the inner leaflet of the membrane. It is involved in signal transduction and apoptosis. An improper ratio of sphingomyelin to ceramide has been shown to be a factor in Niemann-Pick disease3 and neonatal respiratory distress syndrome.4 However, the ratio of sphingomyelin to ceramide is different for different cell types. Sphingomyelin is an important amphiphilic component when plasma lipoprotein pools expand in response to large lipid loads or metabolic abnormalities.
产品描述
mixture of D-erythro and L-threo isomers|N-C17:0-Sphingomyelin
