中文名称

N-十二烷酰基-NBD-乳糖基神经酰胺

英文名字

N-Dodecanoyl-NBD-lactosylceramide

供应商

Matreya

产品货号

1630-50

产品报价

￥询价/50ug

产品说明书

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购买方式

银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868

产品新闻

背景资料

This high purity fluorescent product is ideal for the identification of lactosylceramides in samples and biological systems. NBD has been shown to have only a small influence on lipid adsorption into cells and cellular membranes especially when the fatty acid is a short chain. This fluorescent analog of natural lactosylceramide is comparable to C12:0-ceramide in many biological functions.1 Lactosylceramide is the precursor of many other glycosphingolipids and also functions as a second messenger and protein receptor, making it a very important organic molecule. Many cellular processes are dependent on lactosylceramide since it is the substrate for neutral oligoglycosylceramides and gangliosides, all of which have their own vital functions. Lactosylceramide also helps to stabilize the lipid membrane, activate receptor molecules and acts as a receptor for certain bacteria and toxins. In animals, where it is found mostly in epithelial and neuronal cells, it is expressed on neutrophils and macrophages where it binds to toxins and bacteria, which are then engulfed and eliminated. Its role as a second messenger has been found to be vital and dysfunctions in its processes can lead to cancer and inflammation since it is critical to neutrophil activity and in activating anti-inflammatory responses.2 Therefore, it is being studied for its use in cancer therapies and as a therapy for other diseases. Other examples of lactosylceramide second messenger functions are tumor necrosis factor
and platelet-derived growth factor. A deficiency in the enzyme responsible for hydrolyzing the galactose of lactosylceramide leads to lactosylceramidosis, which is characterized by an accumulation of lactosylceramide that causes a primary neurological disorder.3 Lactosylceramide is also important in the activation of platelet/endothelial cell adhesion molecule-1 which causes adhesion and diapedesis of monocytes/lymphocytes.4

产品描述

N-C12:0-NBD-beta-D-Lactosylsphingosine|N-C12:0-NBD-Lactosylceramide|N-Dodecanoyl-NBD-beta-D-lactosylsphingosine

产品形式

该N-十二烷酰基-NBD-乳糖基神经酰胺产品为固体形式

保存建议

对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

其他

Matreya LLC是一家脂质生化公司，致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富，生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体（生育酚和生育三烯酚）。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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