中文名称

N-十二烷酰基-NBD-L-苏糖二氢鞘氨醇

英文名字

N-Dodecanoyl-NBD-L-threo-dihydrosphingosine

供应商

Matreya

产品货号

1623-100

产品报价

￥询价/100ug

产品说明书

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购买方式

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产品新闻

背景资料

N-Dodecanoyl-NBD-L-threo-dihydrosphingosine is a synthetic dihydroceramide analog containing the 7-(4-nitrobenzo-2- oxa-1,3-diazole) (NBD) fluorescent group. NBD has been shown to have only a small influence on lipid adsorption into cells and cellular membranes in many applications. This fluorescent analog of L-threo-dihydroceramide is comparable to C12:0- L-threo-dihydroceramide in some biological functions. Safingol is a fully saturated, non-natural analog of sphingosine that has anticancer properties and is being investigated for its potential as an antitumor therapy. It has been shown to inhibit both protein kinase C (PKC) and sphingosine kinase. Safingol competitively interacts at the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. Safingol has been shown to potentiate the effect of doxorubicin (DOX) in tumorbearing animals.1 It has been reported that safingol is able to increase the activity of DOX and other chemotherapeutic agents, including mitomycin C, by generating the pro-apoptotic second messenger ceramide, even in tumor cell lines that were resistant to chemotherapy due to mutations.2 However, a study has recently claimed that safingol induces cell death of an exclusively autophagic character and lacking any of the hallmarks of apoptosis.3 Safingol inhibited the reactive oxygen intermediates (ROI) released from isolated neutrophils and phorbol ester-induced edema and neutrophil influx. Safingol also demonstrates anti-inflammatory activity. Safingol, like the natural D-erythro-sphinganine, is used as a biosynthetic precursor for all complex sphingolipids althogh the metabolism of the natural and the non-natural compounds are different.4

产品描述

N-C12:0-NBD-Dihydroceramide|N-C12:0-NBD-L-threo-Dihydrosphingosine

产品形式

该N-十二烷酰基-NBD-L-苏糖二氢鞘氨醇产品为固体形式

保存建议

对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

其他

Matreya LLC是一家脂质生化公司，致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富，生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体（生育酚和生育三烯酚）。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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