该SMAD2 Polyclonal Antibody. Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.
应用类型
WB,IHC-p,ELISA
免疫原
Synthesized peptide derived from human Smad2 around the non-phosphorylation site of Ser250.
