- 中文名称
Phospho-BRCA1(S1423)多克隆抗体
- 英文名字
- Phospho-BRCA1(S1423) Polyclonal Antibody
- 供应商
- Reddot Biotech
- 产品货号
- RD268115A
- 产品报价
- ￥询价/60uL ￥询价/120uL ￥询价/200uL
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- 该Phospho-BRCA1(S1423) Polyclonal Antibody. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
- 应用类型
- WB,IHC,IF
- 免疫原
- A synthetic phosphorylated peptide around S1423 of human BRCA1 (NP_009225.1).
- 来源宿主
- 兔
- 反应性
- 人,小鼠,大鼠
- 保存建议
- 储存于-20 ℃。 避免冻融循环。
- 其他
- Reddot Biotech是由一支拥有35年医疗管理经验团队创办的加拿大本土品牌，其已在ELISA产品线上深耕7个年头，并且仍在不断前进中。产品的质量保证也让其越来越多被“收纳进”文献当中，产品线包括ELISA试剂盒、抗体、少量生化试剂，其中ELISA试剂盒超过6000+，物种类型较多：人；大鼠；小鼠；犬科类；牛科；鱼；鸡；猪；兔；山羊；绵羊；猿；马；豚鼠等，像激素类指标促卵泡素（FSH）、促黄体激素（LH），新冠相关病毒受体ACE2、ACE以及肿瘤免疫相关的指标精氨酸酶（ARG）等已是热门应用指标。
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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