JAK2多克隆抗体-JAK2 Polyclonal Antibody代理/参数/厂家-内参抗体-艾美捷科技有限公司

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背景资料: 该JAK2 Polyclonal Antibody. Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), granulocyte-macrophage colony-stimulating factor (CSF2), thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity). Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

免疫原: Synthesized peptide derived from human JAK2 around the non-phosphorylation site of Tyr1007.

其他: Reddot Biotech是由一支拥有35年医疗管理经验团队创办的加拿大本土品牌，其已在ELISA产品线上深耕7个年头，并且仍在不断前进中。产品的质量保证也让其越来越多被“收纳进”文献当中，产品线包括ELISA试剂盒、抗体、少量生化试剂，其中ELISA试剂盒超过6000+，物种类型较多：人；大鼠；小鼠；犬科类；牛科；鱼；鸡；猪；兔；山羊；绵羊；猿；马；豚鼠等，像激素类指标促卵泡素（FSH）、促黄体激素（LH），新冠相关病毒受体ACE2、ACE以及肿瘤免疫相关的指标精氨酸酶（ARG）等已是热门应用指标。