- 中文名称
PKD1/PKC μ (phospho Tyr463) 抗体
- 英文名字
- PKD1/PKC μ (phospho Tyr463) Antibody
- 供应商
- ProSci
- 产品货号
- PSI-80-011
- 产品报价
- ￥询价/0.1mg
- 产品说明书
- 点击查看
- 购买方式
- 银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868
- 产品新闻
- 背景资料
- Serine/threonine-protein kinase that converts transient diacylglycerol n(DAG) signals into prolonged physiological effects downstream of PKC, and is involved in nthe regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and ntrafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation nby mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, nand plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced napoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal ngrowth factor receptor (EGFR) on dual threonine residues, which leads to the nsuppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and nsubsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 nproteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding nto GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the nheterotrimeric G-protein beta/gamma-subunit complex to maintain the structural nintegrity of the Golgi membranes, and is required for protein transport along the nsecretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport nvesicles that are on their way to the plasma membrane. May act by activating the lipid nkinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of nphosphorylated inositol lipids, which induces a sequential production of DAG, nphosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and ngeneration of specific transport carriers to the cell surface. Under oxidative stress, is nphosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK ncomplex and subsequent nuclear translocation and activation of NFKB1. Involved in cell nmigration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment nin newly forming focal adhesion.
- 应用类型
- WB
- 免疫原
- PKD1/PKC μ (phospho Tyr463) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine463 (R-Y-Y (p)-K-E) derived from Human PKD1/PKC μ.
- 来源宿主
- 兔
- 反应性
- 人, 小鼠, 大鼠
- 保存建议
- Store antibody at -20˚C for up to one year.
- 其他
- ProSci Incorporated于1998年成立于美国加州圣地亚哥市,从事抗体等科研试剂的研发、生产和销售。产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci拥有超过30000种单克隆抗体和多克隆抗体。ProSci的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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