Fmoc-PEG3-Val-Cit is a PEG linker containing an Fmoc-protected amine and enzymatically cleavable Val-Cit group. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The Val-Cit is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
