Thapsigargin环氧（50 ug）-Thapsigargin Epoxide代理/参数/厂家-生化试剂-艾美捷科技有限公司

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背景资料: Thapsigargin, derived from the plant genus Thapsia, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent that induces rapid Ca2+ release from intracellular stores by the inhibition of the sarcoplasmic endoplasmic reticulm Ca2+-dependent ATPase pump without inositol phosphate formation. Thapsigargin-induced depletion of Ca2+ stores causes apoptosis in most cell lines. It has also been shown to cause histamine secretion from rat mast cells, and to stimulate arachidonic acid metabolism in macrophages. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in skin. Thapsigargin Epoxide can be used as a negative control for Thapsigargin activity.

产品形式: Thapsigargin, derived from the plant genus Thapsia, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent that induces rapid Ca2+ release from intracellular stores by the inhibition of the sarcoplasmic endoplasmic reticulm Ca2+-dependent ATPase pump without inositol phosphate formation. Thapsigargin-induced depletion of Ca2+ stores causes apoptosis in most cell lines. It has also been shown to cause histamine secretion from rat mast cells, and to stimulate arachidonic acid metabolism in macrophages. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in skin. Thapsigargin Epoxide can be used as a negative control for Thapsigargin activity.

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