tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcolasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store operated Ca2+ depletion. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion.
产品描述
A Potent Inhibitor of Sarcolasmic Reticulum Ca2+ ATPase
产品形式
tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcolasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store operated Ca2+ depletion. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion.
