TTA-P2 is a novel, potent and selective T-type CaV blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state.nTTA-P2 has the potential of acting as an antinociceptive agent.
产品描述
A Blocker of T-type CaV Channels
产品形式
TTA-P2 is a novel, potent and selective T-type CaV blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state.nTTA-P2 has the potential of acting as an antinociceptive agent.
