Tityustoxin-Kα was originally isolated from the scorpion Tityus serrulatus, and was shown to block cloned KV1.2 with high potency. It inhibits stably expressed KV1.2 channels in fibroblast cell line as assessed by patch clamp with Kd of 0.21 nM. Tityustoxin-Kα also reduced the binding of I-α-Dendrotoxin to synaptosomal membranes.
产品描述
Voltage-gated K+ channel blocker
产品形式
Tityustoxin-Kα was originally isolated from the scorpion Tityus serrulatus, and was shown to block cloned KV1.2 with high potency. It inhibits stably expressed KV1.2 channels in fibroblast cell line as assessed by patch clamp with Kd of 0.21 nM. Tityustoxin-Kα also reduced the binding of I-α-Dendrotoxin to synaptosomal membranes.