Jingzhaotoxin-XII (JZTX-XII), a 29-residue polypeptide, isolated from the venom of Chinese tarantula Chilobrachys jingzhao. JZTX-XII is specific for the Kv4.1 channel and has high selectivity to the NaV channel isoform expressed in cardiac myocytes. It interacts with the channels by modifying the gating behavior. JZTX-XII blocks KV4.1 currents with an IC50 value of 363 nM in X. laevis oocytes and can inhibit NaV1.5 with an IC50 value of 348 nM.
产品描述
A Blocker of KV4.1 and NaV1.5 Voltage-Gated Channels
产品形式
Voltage-gated K+ (KV) channels play important roles in regulating the excitability of myocytes and neurons. KV channel α subunits are divided into four major subfamilies, Kv1 through KV4. The KV4 (Shal) subfamily comprises three distinct genes, KV4.1, KV4.2, and KV4.3.
