中文名称

Huwentoxin-IV（5 x 50微克）

英文名字

Huwentoxin-IV

供应商

Alomone

产品货号

ALO-STH-100-5x50

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Huwentoxin-IV is a 35 amino acid peptidyl toxin isolated from the tarantula Haplopelma schmidti venom and its structure represents a typical cystine knot motif. Huwentoxin-IV acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated Na+ channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits central neuronal voltage-gated Na+ channel subtypes: hNav1.7 (IC50 of 26 nM), rNav1.2 (IC50 of 150 nM), and rNav1.3 (IC50 of 338 nM), compared with muscle subtypes rNav1.4 and hNav1.5 (IC50 is > 10 µM). Huwentoxin-IV inhibits Na+ channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.

产品描述

A Potent Blocker of Neuronal TTX-Sensitive Voltage-Gated Na+ Channel

产品形式

Huwentoxin-IV is a 35 amino acid peptidyl toxin isolated from the tarantula Haplopelma schmidti venom and its structure represents a typical cystine knot motif. Huwentoxin-IV acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated Na+ channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits central neuronal voltage-gated Na+ channel subtypes: hNav1.7 (IC50 of 26 nM), rNav1.2 (IC50 of 150 nM), and rNav1.3 (IC50 of 338 nM), compared with muscle subtypes rNav1.4 and hNav1.5 (IC50 is > 10 µM). Huwentoxin-IV inhibits Na+ channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.

保存建议

艾美捷为您提供的Alonmone Labs原装进口的Huwentoxin-IV (5 x 50 µg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他

Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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