ω-Grammotoxin SIA is a native toxin isolated from venom of the South American Tarantula spider Grammostola spatulata. ω-Grammotoxin SIA potently inhibits both Cav2.1 (P-type) and Cav2.2 (N-type) Ca2+ channels by altering the voltage-dependence of channel gating. ω-Grammotoxin SIA caused a concentration-dependent and virtually complete inhibition of K+-evoked influx of 45Ca2+ into either rat or chick brain synaptosomes.ω-Grammotoxin SIA at 1 µM, a maximally effective concentration, blocked 52% of IBa in cultured rat hippocampal neurons. A concentration of >50 nM toxin completely inhibited Ca2+ currents in Purkinje neurons (predominantly, P-type channels) and in sympathetic neurons (predominantly, N-type channels).
产品描述
A Novel Blocker of CaV2.1 (P-type) and CaV2.2 (N-type) CaV Channels
产品形式
ω-Grammotoxin SIA is a native toxin isolated from venom of the South American Tarantula spider Grammostola spatulata. ω-Grammotoxin SIA potently inhibits both Cav2.1 (P-type) and Cav2.2 (N-type) Ca2+ channels by altering the voltage-dependence of channel gating. ω-Grammotoxin SIA caused a concentration-dependent and virtually complete inhibition of K+-evoked influx of 45Ca2+ into either rat or chick brain synaptosomes.ω-Grammotoxin SIA at 1 µM, a maximally effective concentration, blocked 52% of IBa in cultured rat hippocampal neurons. A concentration of >50 nM toxin completely inhibited Ca2+ currents in Purkinje neurons (predominantly, P-type channels) and in sympathetic neurons (predominantly, N-type channels).
保存建议
艾美捷为您提供的Alonmone Labs原装进口的Omega-Grammotoxin SIA (5 µg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。
