Oleoyl ethanolamide （OEA） is an analog of the endocannabinoid AEA found in brain tissue and in chocolate. It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue， but its biosynthesis is reduced in the intestine of rats following food deprivation. OEA is an endogenous， potent agonist for PPAR.alpha.， exhibiting an EC50 value of 120 nM in a transactivation assay. Systemic administration of OEA suppresses food intake and reduces weight gain in rats （10 mg/kg intraperitoneally） and PPAR.alpha. wild-type mice， but not in PPAR.alpha. knockout mice. These data indicate that OEA regulates food intake by a PPAR.alpha.-mediated mechanism.
产品描述
An analog of the endocannabinoid AEA found in brain tissue and in chocolate whose biosynthesis is reduced in the intestine of rats following food deprivation； an endogenous， potent agonist for PPARα （EC50 = 120 nM in a transactivation assay）； systemic administration suppresses food intake and reduces weight gain in rats （10 mg/kg intraperitoneally） and PPARα wild type mice， but not in PPARα knockout mice
