Several different arachidonoyl amino acids， including N-arachidonoyl dopamine （NADA）， have been isolated and characterized from bovine brain. NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective agonist， inducing the typical tetrad of hypothermia， analgesia， catalepsy， and hypomotility in rats which exceeds that of anandamide （AEA）. NADA is a full agonist at the vanilloid receptor 1， but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor （IC50 = 0.25 uM） of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.
产品描述
The amide of the neurotransmitter dopamine and arachidonic acid； a CB1-selective agonist that induces hypothermia， analgesia， catalepsy， and hypomotility in rats； a full agonist at TRPV1， but inactive at the dopaminergic D1 and D2 receptors； a potent inhibitor （IC50 = 0.25 uM） of the proliferation of MCF-7 breast carcinoma cells
