Several benzimidazole derivatives, developed as synthetic cannabinoid (CB) receptor agonists, have been identified as being selective for the peripheral CB2 receptor.{21225} MCHB-1 is a potent agonist of the human CB2 receptor (EC50 = 0.52 nM) that shows high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively).{21225} Similar benzimidazole compounds significantly reduce peripheral pain with reduced central nervous system side effects in mice.{21221} This product is intended for forensic and research applications.
产品描述
A potent agonist of the human CB2 receptor (EC50 = 0.52 nM) that shows high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively)
