2-Arachidonoyl glycerol （2-AG） has been isolated from porcine brain， and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. The congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group is 2-linoleoyl glycerol （2-LG）， and this compound also appears in vivo in conjunction with 2-AG. Although the intrinsic activity of 2-LG is low， it potentiates the activity of other endocannabinoids， including 2-AG. This ’entourage’ effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release.
产品描述
A congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group that potentiates the activity of other endocannabinoids， including 2-AG； this “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to rapidly reduce endocannabinoid levels following release
