The glyceryl esters of arachidonic acid have been proposed as endogenous cannabinoid ligands. 2-AG is 10 to 100 times more potent than 1-AG in ligand binding affinity and agonist activity at the CB1 receptor， and is thus considered to be the natural ligand. However， 2-AG is chemically unstable and undergoes rapid isomerization to 1-AG （synonymous with 1（3）-AG） both in vitro and in vivo. 1-AG is a frequent contaminant in synthetic 2-AG preparations， and can markedly reduce their cannabinergic potency. 1-AG is a weak CB1 receptor agonist and may have other pharmacologic properties.
产品描述
An endogenous CB receptor ligand that is 10-100 times less potent than 2-AG in ligand binding affinity and agonist activity at the CB1 receptor； 2-AG undergoes rapid isomerization to 1-AG， which makes it a frequent contaminant in synthetic 2-AG preparations， markedly reducing their cannabinergic potency
