中文名称

重组人真核起始因子4E（GST标签）（25ug）

英文名字

eIF4E (human recombinant; GST-tagged)

供应商

Cayman Chemical

产品货号

15564-25

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA.{25365} The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E, and eIF4G1/eIF4G3.{25357} The 5’-terminal end of eukaryotic mRNA has a common cap structure that is important for stabilizing mRNA and ribosome binding.{25366} The eIF4E component binds specifically to the mRNA cap structure to initiate protein synthesis by recognizing methyl-7-guanosine.{25357,25363} eIFA is a DEAD-box helicase, responsible for unwinding the mRNA, while eIF4G acts as a scaffold protein with binding sites for the poly(A)-binding protein and eIF3. eIF4G also possesses central and C-terminal eIF4A binding sites and a C-terminal binding site for the protein kinase Mnk1 (mitogen-activated protein kinase-interacting kinase).{25364} Mnk1 phosphorylates eIF4E at Ser209, which is believed to be essential for eIF4E’s oncogenic potential.{25361,25359,25360} Further, overexpression of eIF4e is seen in many human malignancies, including breast, colon, head and neck carcinomas, and others.{25358,25362}

产品描述

提供的重组人真核起始因子4E（GST标签）（25ug）产品形式为：50 mM sodium bicarbonate, pH 8.6, containing 100 mM sodium chloride and 5% glycerol.

产品形式

Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA.{25365} The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E, and eIF4G1/eIF4G3.{25357} The 5��-terminal end of eukaryotic mRNA has a common cap structure that is important for stabilizing mRNA and ribosome binding.{25366} The eIF4E component binds specifically to the mRNA cap structure to initiate protein synthesis by recognizing methyl-7-guanosine.{25357,25363} eIFA is a DEAD-box helicase, responsible for unwinding the mRNA, while eIF4G acts as a scaffold protein with binding sites for the poly(A)-binding protein and eIF3. eIF4G also possesses central and C-terminal eIF4A binding sites and a C-terminal binding site for the protein kinase Mnk1 (mitogen-activated protein kinase-interacting kinase).{25364} Mnk1 phosphorylates eIF4E at Ser209, which is believed to be essential for eIF4E��s oncogenic potential.{25361,25359,25360} Further, overexpression of eIF4e is seen in many human malignancies, including breast, colon, head and neck carcinomas, and others.{25358,25362}

保存建议

建议您在收到Cayman Chemical品牌的重组人真核起始因子4E（GST标签）（25ug）产品后置于-80度保存，产品有效期为180天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

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