中文名称

重组人苯邻二酚-O-甲基转移酶（50ug）

英文名字

Catechol O-Methyltransferase (human recombinant)

供应商

Cayman Chemical

产品货号

15563-50

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Catechol-O-methyltransferase (COMT) plays an important role in normal brain function and has been implicated in human disorders, such as Parkinson's disease. Using S-adenosyl-L-methionine (SAM) as a methyl donor, COMT methylates catechol substrates, which include neurotransmitters, such as dopamine, norepinephrine, epinephrine, and catecholestrogens; ascorbic acid; and carcinogenic flavonoids.{26885} There are two classes of COMT, the soluble cytosolic form (S-COMT), and the rough endoplasmic reticulum membrane bound form (MB-COMT).{26887} Both forms are coded by a single gene using two separate promoters.{26887} Cayman’s COMT is the soluble S-COMT isoform and is composed of 221 amino acids, whereas MB-COMT has an additional 50 amino acid residues, including 21 hydrophobic amino acid residues that compose the membrane anchor region.{26884} While S-COMT is predominate in most tissues, MB-COMT is found in higher concentrations in the brain.{26888} A common variant in exon 4 of the COMT gene leads to a substitution of valine by methionine,Val158Met, which affects the stability of COMT and may diminish activity by 50% in the human brain. Since COMT is one of the primary regulators of prefrontal cortex dopamine levels, it plays an important role in cognition.{26886}

产品描述

提供的重组人苯邻二酚-O-甲基转移酶（50ug）产品形式为：50mM Tris-HCl, pH 8.0, containing 500 mM sodium chloride.

产品形式

Catechol-O-methyltransferase (COMT) plays an important role in normal brain function and has been implicated in human disorders, such as Parkinson's disease. Using S-adenosyl-L-methionine (SAM) as a methyl donor, COMT methylates catechol substrates, which include neurotransmitters, such as dopamine, norepinephrine, epinephrine, and catecholestrogens; ascorbic acid; and carcinogenic flavonoids.{26885} There are two classes of COMT, the soluble cytosolic form (S-COMT), and the rough endoplasmic reticulum membrane bound form (MB-COMT).{26887} Both forms are coded by a single gene using two separate promoters.{26887} Cayman��s COMT is the soluble S-COMT isoform and is composed of 221 amino acids, whereas MB-COMT has an additional 50 amino acid residues, including 21 hydrophobic amino acid residues that compose the membrane anchor region.{26884} While S-COMT is predominate in most tissues, MB-COMT is found in higher concentrations in the brain.{26888} A common variant in exon 4 of the COMT gene leads to a substitution of valine by methionine,Val158Met, which affects the stability of COMT and may diminish activity by 50% in the human brain. Since COMT is one of the primary regulators of prefrontal cortex dopamine levels, it plays an important role in cognition.{26886}

保存建议

建议您在收到Cayman Chemical品牌的重组人苯邻二酚-O-甲基转移酶（50ug）产品后置于-80度保存，产品有效期为180天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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